取蟾蜍若干，缚后腿，倒悬于烟囱。三日，蟾力竭，垂涎，小虫杂间。盘中置黄蜡，引涎，混匀为膏，可退瘟疫。蟾旋死。

Sir Isaac Newton, the polymath who discovered gravity in his early twenties and is credited with groundbreaking advances in calculus, physics and optics, took notes on a possible cure for the plague that no doctor today could recommend.

In a previously unpublished two-page manuscript dating to 1667, Newton wrote that to cure the plague, "the best is a toad suspended by the legs in a chimney for three days, which at last vomited up earth with various insects in it, onto a dish of yellow wax, and shortly after died."

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这是故事编的好，这方法普通人也想不到。