【zt】王立铭·2019新型冠状病毒的来龙去脉

  • b
    bbfaye
  • M
    Macd10
    这篇真好!解释了之前D版有人问为什么要找中间宿主的问题。 iOS fly ~
  • f
    flamesky08
    写的很好
  • q
    qiuike
    嗯,蛮好的文章。
  • c
    connors
    现在很多地方都延迟到10号上班,就能够保证大部分人隔离14天了
  • b
    beautydevil
    谁转个友好点的链接吧
  • w
    wwtbyr
  • d
    davidchiu
    解释得非常明白
  • d
    danety
    逻辑非常清晰 iOS fly ~
  • z
    zhaoyuping
    不错!!!!
  • w
    winhoo
    挺好的文章
  • b
    borner
    总算有明白人出来了
  • 咸鱼翻身
    严格证明。。。这个词用的妥
  • b
    beautydevil
    回复7#wwtbyr
    谢谢,可以了!
  • s
    stevenflp
    挺棒。 iOS fly ~
  • 狡兔
    世卫6天前说R0预计为1.4-2.5,但世卫这个数据应该是有问题的,因为世卫近日已经将全球风险等级由中调为高,R0是很重要的依据。

    香港大学医学院院长,传染病专家梁卓伟认为R0是3.6-4.0,这个就非常可怕了,希望他专业能力不行吧。
  • j
    jrsdhr
    这人的文章还在说从23日的数据看他保持高度乐观,23日以后是个什么情况?大家都看到了。
  • c
    cd2050
    马克……
  • v
    viaj
    谢谢科普,读完了。HiPDA·NG
  • 流浪的木瓜
    看传播力那么低,看不下去了
  • 鱼儿的小池塘
    这个结论应该被现在的数据打脸了,传播力已经明显超过,连眼睛有创口都能传染,毒力估计可能不如



    iOS fly ~
  • b
    bbfaye
    王立铭文中所说的他倾向相信WHO的R0预估,这个R0预估1.4~2.5是WHO 2019.1.22~23日的会议声明中说的,并明确表明了是当前预估:
    http://www.who.int/news-room/detail/23-01-2020-statement-on-the-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov)

    1. The following elements were considered as critical:Human-to-human transmission is occurring and a preliminary R0 estimate of 1.4-2.5 was presented. Amplification has occurred in one health care facility. Of confirmed cases, 25% are reported to be severe. The source is still unknown (most likely an animal reservoir) and the extent of human-to-human transmission is still not clear.
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    事实上,WHO的这个数据应该也是严谨的,不是张嘴就来,一种很显然的测算方法是对比SARS和MERS,可以参考 Global Biosecurity上的一段说明:
    http://jglobalbiosecurity.com/articles/51/

    1. This is a new infection, so it can only be compared with SARS and MERS CoV.It initially appeared less infectious than SARS, which had a R0 of about 2 but more infectious than MERS CoV, which has a R0 close to 1. Some experts are estimating R0 to be 3 or higher, based on the surge in cases in late January. However, such estimates do not factor in increased awareness, testing and reporting as a factor in the surge in reported cases. We also cannot rule out a large point-source outbreak with some person-to person transmission. The epidemiologic picture of a localised epicentre (more cases in Hubei than other parts of China, and the vast majority of cases in China) does not support a R0 of >3. In many reported cases, the disease seems to have a long, mild prodromal phase before people become severely ill and present to hospital, so we need better estimates of R0 based on actual onset date of symptoms (rather than date of case report). In terms of case fatality rate (CFR), the CFR with SARS was 12%, MERS CoV 26-30% and 2019nCoV appears to be about 2-3% based on informal reports of cases and deaths.The transmission appears mixed (like MERS CoV), with the initial picture mostly a point-source outbreak and some propagated transmission from person to person in families and in a health care setting (3). With SARS, travel-related cases in other countries frequently caused satellite epidemics with clear person to person transmission in Hong Kong, Vietnam, Singapore and Canada. This has not been seen so far with the new coronavirus, although 62 cases have been reported in 15 other countries. With MERS, the only outbreak outside of the Kingdom of Saudi Arabia was in South Korea, and over 60% of cases are sporadic (8).
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    我不是专业人士,但是可以理解,R0的测算是非常复杂的,也会受后续的病毒变异、防疫措施影响而变动,最终这个病毒整体疫情中R0如何,等尘埃落定后我们再看吧。


    王立铭的文章篇幅不长,浅显易懂,其中最关键的一句我认为是楼上某位朋友所说的:1月24日严格证明了病毒的人传人能力。
    这种科普文章不可能像学术论文这么严谨,大家取其精华即可。
  • 胖菜鸟
    非常棒的文章,已拜读已转发美版ip7p iOS12 128G 无锁了!
  • m
    mingchenzs
    人类会不会最终被病菌消灭?
  • b
    bingzhimuxue
    回复25#bingzhimuxue
    链接中*号被论坛和谐了 不做更正 iOS fly ~
  • b
    bbfaye
    链接很多需要重新编辑一下。没详细看,瞄了一眼香港中文大学那个24日发在biorvix的论文,内容很粗糙,用个简单的统计模型就来预测,感觉就是来蹭热点的。
  • d
    daddle
    学到知识就是好文章。
  • y
    yuren238
    不懂,这个有什么问题,不是要经过人体实验,那样疫情早过了HiPDA怪兽版